Deuche adult chat
The lack of neutralising antibodies against the CHAT strain in persons vaccinated with OPV might be associated with an increased risk of reinfection with the CHAT polio virus type 1, and this implies a putative risk of transmission of the virus to polio-free communities.We strongly suggest that laboratory workers who were immunised with OPV receive a booster vaccination with IPV before handling CHAT in the laboratory.In a previous study, the immunity status of 10 members of the laboratory staff with OPV history against CHAT was analysed using neutralisation test to estimate the potential risk of laboratory-associated infections and transmission to the community.Seven of the samples had the antibody titres against CHAT more than twofold lower than those against poliovirus type 1 Sabin, and three of them had the titres less than 8 [Group I included sera from 41 adults.
The majority of our laboratory staff was vaccinated before 1998 with Sabin strain LSc-2ab.
For instance, the European Committee for Standardization Technical Committee 216 - Chemical Disinfectants and Antiseptics (CEN/TC 216) developed a European standard that comprises a virucidal quantitative suspension test for chemical disinfectants and antiseptics used in human medicine (EN 14405 A06) .
According to the European standard EN 14476, Sabin poliovirus type 1 vaccine LSc-2ab is one of the test viruses.
Generally, small non-enveloped viruses such as picornaviruses are very resistant to biocides.
Therefore, poliovirus has been most widely used for virucidal testing.